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How to get diabetic nephropathy

2017-02-06 14:57

The occurrence of diabetic nephropathy is closely related to high blood glucose, and poor blood glucose control can accelerate the occurrence and development of diabetic nephropathy. The formation of mesangial cells proliferation, extracellular matrix increased, mesangial expansion, glomerular basement membrane thickening and so on.

Diabetic nephropathy is one of the common complications of diabetes, but also an important cause of death of patients, but many people have limited knowledge of diabetes, it is not clear that the cause of diabetic nephropathy.
So what are the causes of diabetic nephropathy?

1, hypertension. Hypertension and diabetic nephropathy has no direct relationship, but the deterioration of the original hypertension or course to microalbuminuria period after high blood pressure can accelerate the progression of diabetic nephropathy and renal function, increased urinary albumin excretion.

2, high blood sugar. The occurrence of diabetic nephropathy is closely related to high blood glucose, and poor blood glucose control can accelerate the occurrence and development of diabetic nephropathy. The formation of mesangial cells proliferation, extracellular matrix increased, mesangial expansion, glomerular basement membrane thickening and so on.

3, abnormal renal blood flow. High blood glucose, glomerular hypertransfusion and hyperfiltration, increased transcapillary pressure, the expansion of mesangial cells, and generate dense droplets of fusion of epithelial foot processes, glomerular epithelial cell shedding from the basilar membrane. Glomerular basement membrane collagen messenger RNA in the basement membrane thickening, eventually forming a diffuse mesangial nodules, occurrence of glomerular sclerosis. In the case of high pressure, the increase of protein filtration can also be deposited in the mesangial area and glomerular basement membrane, promote matrix proliferation, forming a vicious cycle, and can cause nodular and diffuse glomerulosclerosis.

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