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What are the causes of diabetic nephropathy

2017-02-10 09:50

Genetic etiology of diabetic nephropathy. A recent study found that diabetic nephropathy also showed family aggregation in some family history of hypertension in patients with diabetes, the incidence of diabetic nephropathy were significantly higher than those without family history of hypertension patients. In addition, there was a difference in the incidence of diabetic nephropathy among different ethnic groups. All these indicate that the incidence of diabetic nephropathy is related to genetic factors.

Two, the etiology of diabetic nephropathy hypertension. There is no direct relationship with the occurrence of diabetic nephropathy, but the original hypertension or during the course of the disease when the blood pressure increased to accelerate the progression of diabetic nephropathy and deterioration of renal function, increase the excretion of urinary albumin.

Three, the cause of diabetic nephropathy - hyperglycemia. The occurrence of diabetic nephropathy is closely related to high blood glucose, and poor blood glucose control can accelerate the occurrence and development of diabetic nephropathy. The formation of mesangial cells proliferation, extracellular matrix increased, mesangial expansion, glomerular basement membrane thickening and so on.

Four, the etiology of diabetic nephropathy renal hemodynamic abnormalities. In diabetic nephropathy, plays a key role, and may be the initial factor.

1) high blood glucose, glomerular hypertransfusion and hyperfiltration, increased transcapillary pressure, the expansion of mesangial cells, and generate dense droplets of fusion of epithelial foot processes, glomerular epithelial cell shedding from the basilar membrane.
2. Under the condition of high pressure, the increase of protein filtration can also be deposited in the mesangial area and the glomerular basement membrane, promote the proliferation of matrix, form a vicious cycle, and can cause nodular and diffuse glomerulosclerosis.
3) glomerular basement membrane collagen messenger RNA in the basement membrane thickening, eventually forming a diffuse mesangial nodules, occurrence of glomerular sclerosis.

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