Diabetic nephropathy is a common complication of diabetes2017-01-24 14:27
Diabetic nephropathy is a common complication of diabetes, is also one of the main causes of death in patients with diabetes. In the United States, first with end-stage renal failure of diabetic nephropathy, is approximately 35% to 38%. Even though the clinic relies on improving metabolic control and other interventions trying to slow its progress, but with the relentless decay of renal function, many patients still inevitably into the renal failure stage, which led to an urgent need for new treatments.
The study in mice in vivo and in vitro models of observed that broccoli from food and medicinal herbs cinnamon extracts of sulforaphane and cinnamaldehyde two substances, can be reduced by common disorders of glucose metabolism, improvement of glucose metabolism disorder caused by diabetes and kidney damage, therapy for clinical diabetic nephropathy by exploring a new path.
1, high blood pressure. Relationship between hypertension and diabetic nephropathy is not directly, but the original hypertension or course to trace protein in urine when blood pressure increases after diabetes nephropathy advances and deterioration in renal function, increased urinary albumin excretion.
2, high blood sugar. Diabetic nephropathy are closely related to high blood sugar, poor blood sugar control may accelerate the development of diabetic nephropathy, good blood sugar control can significantly slow down their development. High blood glucose and glycation end-product caused by increased proliferation of mesangial cells and extracellular matrix increased mesangial expansion, Glomerular basement membrane thickening.
3, abnormal renal blood flow. When blood sugar is high, high infusion in glomeruli, and Hyperfiltration, transcapillary pressure increased, mesangial cell expansion, epithelial foot processes fusion and produces dense droplets on Glomerular basement membrane in epithelial cells from shedding. Glomerular basement membrane type IV collagen Messenger nucleic acid of sugar increased thickening of the basement membrane.