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Diabetic nephropathy complications

2017-04-26 18:04

Diabetic nephropathy has a longer course of disease, and diabetes mellitus is often accompanied by a variety of complications. All kinds of infection is obviously ketoacidosis may be serious complications; performance of disease progression; microvascular disease based on nephropathy, retinopathy, neuropathy and other important pathological diabetic chronic complications, but macrovascular disease such as atherosclerosis and heart, brain, kidney disease and hypertension associated with diabetes, can also be found in patients without diabetes and whether complications require specific analysis.
(1) diabetic ketoacidosis and coma
(2) hyperosmolar nonketotic diabetic coma
(3) diabetes lactic acidosis
(4) infection is common in the following groups:
1 skin infection. Such as ringworm, tinea pedis and carb nail rot, Le purulent infection is common, sometimes causing septicemia.
2 tuberculosis. In particular, tuberculosis, once the disease, rapid expansion, widespread, more lesions, exudative cases of pneumonia prone, the incidence rate of 3 ~ 5 times higher than the average person. With the control of tuberculosis and other fluctuations.
3 urinary tract infection. Pyelonephritis is more common, sometimes accompanied by fungal vaginitis, infection is not easy to control, we must strictly control diabetes at the same time, in order to obtain better results. Domestic necrotizing renal papillary inflammation rare.
4 gallbladder, cholangitis, cholelithiasis, periodontitis, gingival sinusitis and sinusitis.
(5) cardiovascular disease. It is the most serious and prominent problem, accounting for 70% of the causes of diabetes deaths. Basic pathology of atherosclerosis and microvascular disease. The incidence of atherosclerosis was much higher than that of normal people, which occurred earlier and developed more rapidly. Cardiovascular disease in patients with diabetes in China is lower than that reported in foreign countries, especially myocardial infarction, angina pectoris and gangrene. The pathogenesis of this disease and the relationship has not been elucidated, lipid mucopolysaccharide metabolism, especially triglycerides, cholesterol and other blood concentration, HDL2, Ch decreased, more often than this group of diabetic or non-diabetic patients of such lesions is heavy, show that the important factor in the pathogenesis of metabolic disorders such as atherosclerosis in diabetes mellitus. In addition to coronary heart disease has been noted in recent years diabetic cardiomyopathy. 1 cases died of cardiogenic shock, acute heart failure in our hospital autopsy found no myocardial infarction, but observed coronary artery thrombosis obstruction most lumen, accompanied by myocardial lesions widely (focal necrosis) and myocardial microvascular disease. And from the cardiovascular function of nerve function, early detection of vagus nerve injury prone, tachycardia, sympathetic nerve may also be involved in the regulation of advanced similar non nerve transplantation in heart formation, resulting in painless myocardial infarction, severe arrhythmia, often leading to cardiogenic shock, acute heart failure and violence, we have found that many cases, said diabetic heart disease, including diabetic cardiomyopathy, cardiovascular autonomic diabetic neuropathy and / or hypertension and coronary heart disease. While this is still controversial, the WHO diabetes group and most scholars have been recognized. The clinical use of noninvasive early diagnosis help check, such as echocardiography, left ventricular function of myocardial radionuclide examination, Pan Shengting development, analysis of the electrocardiographic RR interval spectrum; traumatic examination such as catheter angiography help diagnosis. In BB rats, the experimental results show that the first manifestation of diabetic heart disease is cardiomyopathy, and the pathological location, the mechanism remains to be studied in animal model of. The pathogenesis of microvascular disease including blood rheology, hyper perfusion, ultrafiltration, microvascular basement membrane thickening, increased blood viscosity, abnormal blood coagulation, microcirculation and other various factors, in recent years, tissue proteins such as hemoglobin HbA1C, glycosylated lipoprotein, glycosylated collagen, the increase of free radicals, resulting in advanced glycation end products (AGE) the accumulation of damage and tissue hypoxia is closely related.

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