Three main causes of diabetic nephropathy2017-05-22 15:56
Diabetic nephropathy (DN) is one of the common complications of diabetes. It is also an important reason leading to the death of patients. However, many people do not know the cause of diabetic nephropathy because of their limited knowledge of diabetes. What are the causes of diabetic nephropathy?
1, hypertension. Hypertension and diabetic nephropathy has no direct relationship, but the deterioration of the original hypertension or course to microalbuminuria period after high blood pressure can accelerate the progression of diabetic nephropathy and renal function, increased urinary albumin excretion.
2, high blood sugar. The occurrence of diabetic nephropathy is closely related to hyperglycemia. Poor glycemic control can accelerate the occurrence and development of diabetic nephropathy. Good glycemic control can significantly delay the development of diabetic nephropathy. Increased production of hyperglycemia and glycation end products cause mesangial cell proliferation, increased extracellular matrix, mesangial expansion, and thickening of the glomerular basement membrane.
3. Abnormal renal blood flow. High blood glucose, glomerular hypertransfusion and hyperfiltration, increased transcapillary pressure, the expansion of mesangial cells, and generate dense droplets of fusion of epithelial foot processes, glomerular epithelial cell shedding from the basilar membrane. The glomerular basement membrane type IV collagen messenger nucleic acid increases, resulting in thickening of basement membrane and eventually formation of diffuse and nodular lesions of the mesangial tract, which leads to glomerulosclerosis. In the case of increased pressure, increased protein filtration can also be deposited in the mesangial region and the glomerular basement membrane, promoting matrix hyperplasia, forming a vicious cycle, and can cause nodular and diffuse glomerulosclerosis.