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What are the symptoms of primary nephritis

2017-03-16 10:49


Nephritis is not a independent nephritic disease, but a kind of nephritic syndrome with glomerular damaged, the same or similar symptoms. In clinical practice, what are the symptoms of nephritis disease? One to three weeks ago, there is respiratory or skin infection, such as acute pharyngitis, tonsillitis, gum abscess, scarlet fever, measles, chickenpox, impetigo and so on, some patients have no premonitory symptoms.


1,hematuria,  gross hematuria is often the first symptom(about 40-70%), urine is dark and turbid browenish red or wash meat water, usually disappear in a few days, also last for 1-2 weeks to microscopic hematuria, microscopic hematuria disappeared in 6 months, also sustainable 1-3 years.


2,swelling,  there are about 70% patients have the edema as the first symptom, edema occurs in the face, eyelids. Eyelids, facial edema and pale, showing the so-called nephritis face. Edema can also spread to the lower limbs, when severe there are hydrothorax and ascite and pericardial effusion.


3,oliguria, no urine. Less than 400ml/24h called oliguria, less than 100ml/24h called no urine.


Glomerular endothelial cell proliferation, capillary lumen stenosis or occlusion, glomerular filtration rate decreased, such as proliferative glomerulonephritis, proliferative glomerulonephritis, etc..


The large number of crescent formation, blocking the renal capsule, such as cresentic glomerulonephritis.


Most of the renal units were destroyed and the original urine was difficult to produce, such as sclerosing glomerulonephritis.


4,proteinuria, due to a variety of inflammatory mediators and vasoactive substances in blood vessels, so that capillary permeability increased, the protein filtered out, resulting in proteinuria, seen in various types of glomerulonephritis.


In addition, blood pressure can be increased from mild to moderate, the general adult is 20~21.3/12~14.7kpa, with the increase of urine volume, blood pressure tends to normal, generally lasting 2-4 weeks. A few patients may be due to a sharp increase in blood pressure (>26.7/17.3kpa) causing hypertensive encephalopathy or left heart failure, high blood pressure and water and sodium retention, renin secretion increased, reduce the secretion of prostaglandin.

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