Systemic Lupus Erythematosus treatment2017-01-14 08:47
(1) the plasmapheresis and immunoadsorption therapy can quickly remove the plasma antigens, antibodies, immune complexes, cytokines and other inflammatory mediators, and to improve the function of the reticuloendothelial system, it can achieve the objective of controlling disease activity. Can be used for type ⅳ lupus nephritis in WHO activities, especially applicable to hormones after blast combined cytotoxic medications cannot control the activity of disease, and rapid deterioration of renal function.
(2) ring spore mold pigment a, (CSA): part patients showed that this drug may from function and the histological aspects protection kidney, prevent immune composite real of kidney calm, prevent nephritis of occurred and protein urine of produced, but cannot reduced anti-DNA antibiotics body or cycle composite real of level, stopped drug Hou recurrence, and liver, and kidney of HIV side effects larger, effect is not certainly.
(3) is being studied for treatment of: thromboxane receptor antagonist, r-globulin and antilymphocyte serum (ACG), antibiotic breast cells antiserum (ATG), anti-CD4 monoclonal antibody.
(4) other: anticoagulation with heparin. The anticoagulant, confrontation of antidiuretic hormone (ADH), additional negative effects such as Glomerular basement membrane, and can still improve Glomerular circulation, diuretic and reducing the role of protein leakage, therapeutic dose of 100 mg/day, pided into two subcutaneous. Against platelets to clump together drug dipyridamole 50-100 mg, three times a day taken by mouth. Reduced Glomerular Hyperfiltration, ACEI, luodingxin 10 mg-40 mg/day, and reduce high blood pressure.
(5) hormone therapy: hormone generally used prednisone as a standard course of treatment. First started therapy, adult LMG/kg ideal body weight, daily morning dose, to start reduction after 8 weeks, weekly 10% (5mg), low dose (the next morning 1mg/kg), next day early morning dose, maintenance dose (the next morning 0.4mg/kg). Had an unusually severe or fulminant, using methylprednisolone 1g/, add 5% 300ml glucose saline, intravenous infusion, 1 times per day for 3 consecutive days. And oral standard course of prednisone.
Notes: (1) diet: lupus nephritis patients should consume enough nutrients, such as protein, vitamins, minerals, light is advisable. Salt water, it is advisable for modest limits. Avoid cigarettes, alcohol or spicy food.
(2) exercise: exercise can improve blood circulation, enhance heart and lung function, maintain muscle, bone toughness. walk, qigong, aerobics don't fatigue. but the joint inflammation is inappropriate activity.
(3) avoid the Sun: Lupus patients are sensitive to sunshine, is the beta caused by the wavelengths of ultraviolet light, sunlight should be avoided.
(4) prevention of infection: patients with lower immunity, very susceptible to bacterial assault, arising out of different organs of infected. Common respiratory tract infections, urinary tract infections, gastrointestinal infections, and problems such as wound infection, be sure to pay attention to their own health and sanitation.
(5) adjust the mood: after patients easily depressed, anxiety, depression, anger, guilt, denial, depression and so on. The relationship between emotions and illness are closely related and influence each other, and pay more attention to patients ' psychological health.