How much do you know about the causes of nephrotic syndrome?2017-01-24 11:02
How much do you know about the causes of nephrotic syndrome?
We all know that the kidneys play in the human body is great, but for the nephrotic syndrome, many people do not understand, in this nephropathy rate is higher in the age of today, to learn more about that is more favorable. So, what is the cause of nephrotic syndrome? Please come to our hospital experts to answer this question for you.
The main causes of nephrotic syndrome are the following:
1 infection of bacterial infection in nephritis after streptococcal infection, bacterial endocarditis, shunt nephritis, leprosy, syphilis, tuberculosis, chronic pyelonephritis with reflux nephropathy; virus infection in hepatitis B, cytomegalovirus, infectious mononucleosis, human immunodeficiency virus; parasite infection in Plasmodium, Toxoplasma gondii, worms, schistosomiasis. Filariasis.
2 drug allergy or poisoning, organic or inorganic organic mercury, gold and silver, penicillamine, two heroin, probenecid, non steroidal anti-inflammatory drugs, tridion drugs; snake venom; pollen, bee sting, vaccine, anti allergy toxin etc..
3 tumor, lung, stomach, colon, breast, ovary, thyroid and other tumors, leukemia and lymphoma, Willm tumor, etc..
4 systemic disease, systemic lupus erythematosus, mixed connective tissue disease, dermatomyositis, Sjogren syndrome, allergic purpura, amyloidosis.
5 metabolic diseases, diabetes mellitus, thyroid diseases.
6 genetic diseases, congenital nephrotic syndrome, Alport syndrome, Fabry disease, sickle cell anemia, nail - patella syndrome, lipodystrophy, familial nephrotic syndrome etc..
7 other eclampsia, chronic allograft rejection, malignant renal sclerosis, renal artery stenosis, etc..
Nephrotic syndrome has the following common complications:
(1) infection: due to the loss of a large number of immunoglobulin in the urine, plasma protein, affecting the formation of antibodies. The use of corticosteroids and cytotoxic drugs, so that patients with decreased systemic resistance, prone to infection, such as skin infection, primary peritonitis, respiratory tract infection, urinary tract infection, and even induce sepsis.
(2) coronary heart disease: nephrotic syndrome patients often have hyperlipidemia and high blood coagulation state, so prone to coronary heart disease. It has been reported that the incidence of myocardial infarction in patients with nephrotic syndrome is 8 times higher than that in normal subjects. Coronary heart disease (CHD) has become the third leading cause of death in nephrotic syndrome (second only to infection and renal failure).
(3) thrombosis: prone to thrombosis in patients with nephrotic syndrome, especially the incidence of membranous nephropathy of up to 25% ~ 40%. The causes of thrombus are edema, patient activity, venous stasis, high blood lipids, blood viscosity increased, the concentration of fibrinogen and high content of V, x, VII and VIII factor increases and the use of adrenal cortical hormone and prone to blood hypercoagulability.
(4): acute renal failure in patients with nephrotic syndrome due to massive proteinuria, hypoalbuminemia and hyperlipidemia, body is in a low blood volume and hypercoagulable state. Vomiting, diarrhea, area of use of anti hypertension drugs and the plenty of diuresis, can decrease the renal blood perfusion suddenly reduced, and the glomerular filtration rate decreased, resulting in acute renal failure. In addition, nephrotic syndrome, renal interstitial edema, protein concentration, the formation of tubular blockage of renal tubules and other factors, can also cause acute renal failure.
(5) electrolyte and metabolic disorders: repeated use of diuretics or long-term unreasonable no salt, can make comprehensive secondary hyponatremia patients with nephropathy; use of adrenal cortical hormone and diuretics lead to a large number of micturition, if not timely supplement of potassium, prone to hypokalemia.
The incidence of nephrotic syndrome is on the rise, the patients for the treatment of the disease should be active, so as to be able to restore the health of the body as soon as possible. If you have any other questions about nephrotic syndrome, you can also contact the experts to conduct a comprehensive exchange, I wish you good health.
The above describes seven aspects for the cause of nephrotic syndrome, for its complications also made five point summary for nephrotic syndrome is very important to prevent the disease course, active treatment is also very important