The concept of nephrotic syndrome2017-02-04 11:33
Christian (Christiansen) in 1932 with nephrotic syndrome (nephroticsyn drome nephrotic syndrome) the term, due to a variety of generalized renal damage in severe proteinuria, and a corresponding set of clinical manifestations, the root and nephropathy similar named nephrotic syndrome. The basic feature of this syndrome is proteinuria. "A lot of" proteinuria is one line for the history of various countries and hospitals have different boundaries, at present our country's definition of no less than 3.5G / d. Most of the foreign is more than 3.og (or 3.5G) /1.73m2.d. Often accompanied by hypoproteinemia (less than 30g), edema, hyperlipidemia.
Although nephrotic syndrome is a group of clinical syndromes with common clinical manifestations, disease, Yin physiology and metabolic changes, and even treatment has a common law. However, because it is a group of syndromes caused by a variety of etiology, pathology and clinical diseases, it has its own characteristics in clinical manifestations, pathogenesis and treatment. Nephrotic syndrome is not the same as a fever or a straight line, and should not be used as a final diagnosis of a disease.
There are different views on the application of this term in nephrotic syndrome. Nephrotic syndrome is a clinical condition, which is caused by a variety of reasons. Has the following characteristics: clinical proteinuria (qualitative + + + or more, for the children more than o.1g / kg quantitative d), hypoproteinemia (serum albumin in children <30g/L, baby <25g/L), hypercholesterolemia (serum cholesterol in children > 5.70mmol / L, >5.20mmol / L baby) and clinical eO obviously swollen common feature the syndrome. Among the above four items, the first condition is necessary. Nephrotic syndrome is more common in pediatric kidney disease. According to the national pediatric kidney disease research group (1986) in six administrative areas in China 20 provinces, municipalities and counties in 105 hospitals in 1982 pediatric urologic disease inpatient pediatric urinary system disease, Diabetes Hospital at the same time the total number of 2.63%, nephrotic syndrome accounted for 21% of urinary tract diseases, after acute nephritis (53%). Beijing Children's Hospital (1988) of the hospital for the past 30 years (from 1956 to 1985) in patients with urinary tract diseases were analyzed, and the findings are similar, the primary nephrotic syndrome accounted for 19.02%. And there is an increasing trend year by year. Nephrotic syndrome accounts for 38.1% of the total number of children under the age of in the first hospital of Beijing Medical University in 1967~1976 in the past 10 years. In children younger than 1 years old, primary glomerular disease with nephrotic syndrome accounts for about 90% of nephrotic syndrome, which is higher than that of adults.
Nephrotic syndrome is a common manifestation of glomerular disease (including glomerulonephritis, nephropathy, lupus, and others), but it should be noted that many glomerular diseases do not show this.