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Etiological factors of nephrotic syndrome

2017-02-07 10:56

The primary cause of nephrotic syndrome
Genetic factors
The incidence of nephrotic syndrome in siblings and twins is about 2%-6%. Sharpies (sand Pulis 1985) investigated the incidence of nephropathy in children with steroid sensitive British born living in Bermingham city was divided three groups of Asians, Africans, Europeans, Asians found the highest incidence, the annual incidence rate of 16/10 million children, the other two groups were 2.6/ 100 thousand, 3.1/10 million children. Feehally (fee Harry 1985) reported the incidence of children with minimal change nephrotic syndrome in Leicester, Asia, children were significantly higher than non Asian children, were 9.4/10 million and 1.3/10 million children. In the British city of Leicester Asian children mostly speak Gujarati Indians, and some to speak the Punjab language the Sikh people or islam. The authors argue that racial and environmental differences are two important factors that may increase the susceptibility to the onset of minimal change nephropathy.
Allergic systemic
Ito studied the HLA antigens of various kidney diseases in children, and pointed out that there were 35.3% allergic factors in NS, and the control group was, which was related to HLA-B40. It has been reported that NS has a history of allergic reactions accounted for 40%.
Immune mechanism
NS is known to be involved in humoral immunity, immune complex formation, and cellular immunity. Elzouki (Ai Road 1984) investigation report, Arabia children with primary nephrotic syndrome, the incidence rate of 11.6. The high incidence of the disease may be related to many factors, such as climate, geography, the type of infection in children, and the genetic characteristics of Arabia population.
Two of the causes of nephrotic syndrome secondary factors
Bacterial infection
Nephritis after streptococcal infection, bacterial endocarditis, shunt nephritis, syphilis, leprosy, chronic pyelonephritis with reflux nephritis.
Viral infection
Hepatitis B, infectious mononucleosis, Cy - tomegalovirus, post - vaccination nephritis.
Parasitic infection
Three day malaria, Toxoplasnosis, Helminthic (sehistoso - miasis).
Poisoning, allergies, organic or inorganic organic mercury, gold, silver, bismuth, penicillamine, heroin, probenecid, trimethadione, Captopril, pollers, venom, bee stings, anti toxin or allergic vaccine.
New biology
Solid tumor (Careinoma or sarcoma): lung, colon, stomach, breast, kidney, thyroid, ovary and other tumors, wilm's tumor.
Leukemia and lymphoma, Hodgkin's disease, non Hodgkin's lymphoma, chronic lymphocytic leukemia and multiple myeloma.
Department of 6L disease
Systemic lupus erythematosus, mixed connective tissue disease, Sjogren syndrome, rheumatoid arthritis, allergic purpura, necrotizing vasculitis, polyarteritis, cryoglobulinemia, sarcoidosis, amyloidosis.
Metabolic disease
Diabetes, mucous edema.
Genetic disease
Alport, syndrome, Fabry 's disease, Nail - patella syndrome, congenital nephrotic syndrome (Finland), familial nephrotic syndrome, sickle cell anemia.
Other causes of nephrotic syndrome
Toxemia of pregnancy, chronic renal allograft rejection, primary malignant renal sclerosis, renal artery stenosis and chronic ulcerative colitis.

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