Why nephrotic syndrome causes kidney failure?2017-08-01 16:34
Renal failure is the most serious complication of nephrotic syndrome, and dialysis treatment is often needed. The causes of renal failure caused by nephrotic syndrome can be divided into the following:
Hemodynamic changes: nephrotic syndrome often hypoalbuminemia and vascular lesions, especially in elderly patients with renal arteriosclerosis, is very sensitive to blood volume and blood pressure, so when the acute hemorrhagic, vomiting and diarrhea caused by fluid loss, surgical injury, a large amount of ascites, diuretic and antihypertensive drug use, can make blood pressure a further decline, lead to renal perfusion decreased abruptly, and the glomerular filtration rate decreases, and because of degeneration and necrosis of tubular epithelial cell swelling, acute ischemia, resulting in renal failure.
Renal interstitial edema, hypoproteinemia can cause edema, also may cause renal interstitial edema, renal interstitial edema of renal tubular compression, the proximal tubule of Bowman capsule increased hydrostatic pressure.
Drug induced acute interstitial nephritis.
Bilateral renal vein thrombosis.
Vasoconstriction: in patients with nephrotic syndrome, increased renin concentration occurs during hypoproteinemia and renin induces contraction of the renal arterioles. This condition is more common in elderly patients with vascular disease.
The concentrated protein tube blocks the distal renal tubule and may be involved in the pathogenesis of nephrotic syndrome with arf.
These are the causes of kidney failure caused by nephrotic syndrome. I hope this will help patients. If there are any other questions, you can leave a message on our website or consult our online expert.