Focal Segmental Glomerulosclerosis common primary2017-02-02 17:08
Focal Segmental Glomerulosclerosis common primary glomerular diseases and its histopathological features are segmental Glomerular scarring, with or without the Glomerular capillaries within the foam cell formation and adhesion. Focal refers to only some of the glomeruli are involved (involved in Glomerular <50%); segmental Glomerular of part leaflet refers to being involved; ball hardened glass refers to the entire glomerulus stages or scar formation. Children, adolescents, for multiple groups.
Cause: focal segmental Glomerular sclerosis has many causes. Poisoning injury, humoral and hemodynamic changes and so on, can all cause the capillary wall injury, macromolecular protein production and retention, immunoglobulin deposits and then combined with the C1q and C3, Podocyte caused degeneration and detachment with the basement membrane.
Residual renal hemodynamic changes, causing compensatory hypertension, perfusion and Glomerular Hyperfiltration, causing epithelial cells and endothelial cells, mesangial cells function abnormally, causing focal segmental sclerosis. This pathological process can be prevented by eating a lot of protein and increased limits reduce protein intake and blood pressure treatment. Microthrombosis induced platelet aggregation and endothelial cell injury, aggravated lesion development; many Focal Segmental Glomerulosclerosis associated with such mechanisms, such as chronic nephritis after streptococcal infection, Chronic Renal Allograft Rejection, reflux nephropathy and analgesic nephropathy.