What are the clinical symptoms of nephrotic syndrome?2017-05-12 14:18
What are the symptoms of nephrotic syndrome? Shijiazhuang kidney disease hospital expert introduction, the basic features of nephrotic syndrome is proteinuria, hypoalbuminemia, edema (height) and hyperlipidemia, the so-called "three high and one low", and other metabolic disorders characterized by a group of clinical syndrome. Here's a detailed description of the Shijiazhuang kidney hospital experts. "" "the nephritic syndrome patient appears" three high one low "after, how should do? Let the experts analyze for you
Shijiazhuang nephropathy hospital experts, nephrotic syndrome clinical symptoms:
1. massive proteinuria
Proteinuria is the most important clinical manifestation of nephrotic syndrome, and it is also the most basic pathophysiological mechanism of nephrotic syndrome. A large amount of albuminuria refers to the amount of >3.5g/d excreted by adult urine. Under normal physiological conditions, the glomerular filtration membrane has a molecular barrier and a barrier to electricity, resulting in an increase in protein content in the urine and a large amount of proteinuria when the absorption capacity of the proximal convoluted tubule is much higher than that of the proximal tubule. On this basis, all factors that increase glomerular pressure and lead to high perfusion and high filtration, such as hypertension, high protein diet or massive infusion of plasma proteins, can increase urinary protein excretion.
Plasma albumin decreased to <30g/L. In nephrotic syndrome, large amounts of albumin are lost from urine, contributing to albumin, hepatic compensatory synthesis and increased renal tubular decomposition. Hypoalbuminemia occurs when albumin synthesis in the liver increases and is insufficient to overcome loss and breakdown. In addition, patients with nephrotic syndrome due to gastrointestinal mucosal edema leading to poor appetite, insufficient protein intake, malabsorption or loss, also aggravate hypoproteinemia.
In nephrotic syndrome, hypoalbuminemia and the decrease of plasma colloid osmotic pressure make the water enter the interstitial space from the lumen of the blood vessel, which is the basic cause of edema in nephrotic syndrome. Recent studies show that about 50% of patients with normal or increased blood volume, plasma renin levels decreased or normal, suggesting that some primary renal sodium and water retention factors play a role in the pathogenesis of edema in nephrotic syndrome.
The cause of nephrotic syndrome complicated with hyperlipidemia has not yet been fully elucidated. High cholesterol and / or hypertriglyceridemia, increased concentrations of LDL, VLDL, and lipoprotein (alpha) in serum, often coexisting with hypoproteinemia. Hypercholesterolemia is mainly caused by increased lipoprotein synthesis in the liver, but reduced catabolism in the surrounding circulation also plays a part. Hypertriglyceridemia is mainly caused by catabolism, and liver synthesis is a secondary factor.
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The above is the expert of the Shijiazhuang kidney disease hospital details about the clinical symptoms of nephrotic syndrome ", hope to be able to cause the attention of people, found in the above symptoms, must be timely to a regular hospital for treatment, to avoid the deterioration of disease. If you have any questions, please click on the online experts, or leave a message for us, the experts for you to answer in detail.