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What are the clinical effects of polycystic kidney disease?

2017-03-04 16:51

Listen to the name of polycystic kidney disease seems very strange, but he is a kind of common hereditary kidney disease, the main manifestation is for bilateral renal cyst appears more than the size of the cyst, were enlarged, eventually destroying the structure and function of the kidney, leading to end-stage renal failure. The incidence rate is low, about 1/1000~1/4000 between the patients who are probably in the past 30~50 years, so called "adult polycystic kidney disease, but the disease can occur at any age, even fetuses have a chance. Let us know about the clinical response of polycystic kidney disease.

1 renal cysts: many of the symptoms of ADPKD patients are closely related to the development of renal cysts. There are multiple cysts in the cortex and medulla of the kidney, the diameter of which is from a few millimeters to a few centimeters, and the size and number of cysts increase gradually with the progress of the disease. The degree of renal cyst enlargement in male patients was higher than that in female patients.

2 pain: back or abdominal pain is the most common symptoms in patients with ADPKD. With age and cyst enlargement symptoms, women were more common. Acute pain or pain suddenly intensified often prompts cyst rupture, stones or blood clots caused by urinary tract obstruction and infection. Chronic pain is mostly caused by the enlargement of the kidney or cyst of the kidney, the renal pedicle and the oppression of adjacent organs. Giant liver cysts can also cause right rib pain. Bleeding: more than 90% of patients had cystic bleeding or gross hematuria. More spontaneous, can also occur after strenuous exercise or trauma. The causes of hematuria include rupture of blood vessels, stones, infections or cancer. General hematuria are self limiting, 2~7 days can disappear. If the bleeding persists for more than 1 weeks or the patient is older than the age of 50, it is necessary to exclude the possibility of carcinogenesis.

3 hypertension: one of the most common early manifestations of ADPKD patients. Of the young ADPKD patients with normal renal function, 50% had higher blood pressure than 140/90mmHg, and almost 100% of patients with end-stage renal disease had hypertension. The level of blood pressure was directly proportional to the size of the kidney and the number of cysts, and increased with age.

4 renal function impairment: early renal function damage is often manifested as a decrease in renal function. Most of the patients aged 40~60 years in cyst growth can maintain normal renal function; once the renal function began to decline, the decline in glomerular filtration rate per year is about 4.4~5.5ml/min, from the development of impaired renal function to end-stage kidney disease for about 10 years.

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