Why creatinine is low ?2017-01-25 14:08
Many patients in the detection will appear high creatinine phenomenon, this is most of the kidney will appear in a situation. Of course, there are some kidney disease patients with low creatinine phenomenon. This is why? Below the editor will tell the patients to uncover mystery.
Due to the kidney caused by various disease, the first is the occurrence of impaired renal cell phenotype, the formation of pathological changes in kidney, stimulation of fibroblasts into myofibroblasts, and invasion to stimulate the normal renal tissue inherent in the same disease, thus forming a kidney from local area to the whole, expand the excitation spread process, thus entered the organic injury period (i.e. renal injury period), this time due to kidney damage caused by continuous, its excretion function decreased, causing toxins such as creatinine accumulation in the body, which appeared in the blood creatinine and urea nitrogen increased in urine creatinine decreased, renal filtration rate decreased etc.. At the same time patients will have hypertension, high edema and other symptoms of the body.
Low serum creatinine can initially explain the kidney detoxification function is good, the diagnostic significance of the disease is not large, it will not appear any symptoms. Of course, if creatinine is 0, the meaning is very different, indicating severe impairment of renal function.
Patients with low serum creatinine or high creatinine should pay attention to it. Creatinine in the human body is mainly creatine production of muscle metabolism, creatinine excreted through the kidney in vitro. Under normal circumstances, due to the relative amount of human muscle stability, so the formation of creatinine is also constant, the level of serum creatinine mainly depends on how much creatinine excreted by the kidney. Kidney compensation is very powerful, if the two kidneys are normal, so long as a kidney have function, blood creatinine can be maintained at normal levels. In other words, kidney injury accounted for more than half of the whole kidney, will cause elevated serum creatinine. Therefore, serum creatinine did not reflect early and mild renal function decline.